Natriuretic Peptides in Chronic Heart Failure
نویسندگان
چکیده
منابع مشابه
Natriuretic peptides in heart failure.
Heart failure is a major global health problem affecting 23 million people worldwide. As more cardiac patients survive and live longer with this progressive disease, heart failure is a condition for which the prevalence will grow. Based solely on clinical presentation, heart failure can be difficult to diagnose since its presentation is complex, with signs and symptoms that are nonspecific and ...
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Both BNP and NT-proBNP are considered to be gold standard biomarkers of HF. Both of these are also incorporated into the majority of the national and international cardiovascular therapy guidelines. However, despite this, our understanding of their very complex nature is still far from being complete and comprehensive. Moreover, the constant development of new approaches in patient care and the...
متن کاملNatriuretic peptides - physiology, pathophysiology and clinical use in heart failure.
The natriuretic peptides - atrial, brain and C-type - were discovered during the last twenty years. Their effects on cardiovascular, renal, cerebral and other tissues through guanylyl cyclase were uncovered. Over the past decade natriuretic peptides (NPs) became a very useful tool in the management of heart failure patients. Results of many clinical trials have shown that BNP and NT-proBNP are ...
متن کاملDesigner natriuretic peptides for heart failure: advanced in clinical development
Background The increasing burden of heart failure (HF) is a major unmet need for new therapeutics. No new drug has been approved for HF for over a decade. The natriuretic peptides as endogenous activators of particulate guanylyl cyclase (GC) receptors represent an unparalleled opportunity for novel therapeutic agents for HF. Specifically, the GC-A receptor activated by ANP and BNP and GCB activ...
متن کاملModulating cGMP in heart failure by novel natriuretic peptides
We recently reported the design, synthesis and biological actions of a novel chimeric natriuretic peptide (NP) fusing the 22-amino acid (AA) sequence of mature C-type natriuretic peptide (CNP), a member of the NP family that is highly conserved among species, with the 15-AA C-terminus of Dendroaspis natriuretic peptide (DNP) that was isolated from the venom of the eastern green mamba snake (Den...
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ژورنال
عنوان ژورنال: Cardiac Failure Review
سال: 2019
ISSN: 2057-7559,2057-7540
DOI: 10.15420/cfr.2018.26.1